Celgene Associate Scientist, Biologics Cell Line Development in Summit, New Jersey
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
Seeking an individual with experience in cell line development and molecular biology to join our Biologics Cell Line Development group. Reporting to the head of Cell Line Development Group, the successful candidate will focus on the development of high producing mammalian cell lines for the production of recombinant therapeutic proteins for clinical development, including monoclonal antibodies, fusion proteins, antibody drug conjugates and bi-specific antibodies.
Responsibilities will include, but are not limited to, the following:
1.Performing key activities associated with production cell line development and optimization including transfection, selection, single cell cloning, high throughput screening, characterization of clonal cell lines using scale-down models, and cell banking
2.Developing and optimizing new protein expression platforms by evaluating various gene constructs and expression systems
3.Developing and performing immunoassays such as Octet, ELISA, Western blots, and FACS analysis
4.Developing high throughput screening methods and evaluating new technologies to support cell line screening
5.Working closely with upstream process development and purification teams to support regular development projects and activities
6.Managing lab equipment set up, maintenance, and lab supplies
7.Establishing cell line development SOPs
8.Writing technical reports and presenting data in project team meetings
MS in biochemical/chemical engineering, biological sciences or relevant discipline and over 2 years of industrial cell line or cell culture process development experience, or BS with over 4 years experience
· Hands-on experience with mammalian cell culture, transfection, and stable line selection
· Hands-on experience with vector construction and routine DNA cloning
· Experience with high throughput screening assays such as Octet,ELISA, and FACS analysis
· Proficient in data analysis and common computer applications
· The candidate must be well organized and have excellent oral and written communication skills
· Demonstrate ability work well in a collaborative team-oriented environment
· Be able to work independently and in a fast paced environment to meet project timelines
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
Associate Scientist, Biologics Cell Line Development
Location: Summit, NJ, US
Job ID: 17000692