Sanofi Group Process Engineer, Upstream Development Biopharmaceutics Development in Framingham, Massachusetts
Process Engineer, Upstream Development Biopharmaceutics Development
Sanofi Genzyme focuses on developing specialty treatments for debilitating diseases that are often difficult to diagnose and treat, providing hope to patients and their families.
Genzyme Corporation (a Sanofi company)and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
Job Responsibilities/Department Description:
The Upstream Development group within Biopharmaceutics Development is responsible for development of protein therapeutic manufacturing processes using mammalian (CHO) cell lines. Group responsibilities include selection of candidate production cell lines, development of Phase I/II clinical upstream processes, and development of Phase III/commercial upstream processes. Activities include determination of cell line stability, initial cell line assessment for manufacturing suitability, cell culture process development, and development of scale-down models. Additionally we coordinate tech transfer to GMP clinical and commercial manufacturing facilities.
Displays strong investigative or technological orientation with independence of experimental design in both cases by performing complex analytical procedures and implementing new techniques. He or she may oversee lower level researchers in the execution, design and interpretation of experiments. He or she contributes to the scientific literature, external conferences and/or scientific patents, where applicable. He or she provides consultation to internal Research and Development groups. He or she may lead some aspect of a project in a small lab group. He or she has good presentation, written, and oral communication skills.
Duties for this position:
Develop biopharmaceutical manufacturing upstream processes including experimental design and execution
Lead project teams and work collaboratively within the department as well as collaborations with other departments
Implement novel automation solutions for cell culture operations
BS degree in Chemical Engineering or a related discipline and 8 years relevant experience or MS degree in Chemical Engineering or a related discipline and 6 years relevant experience or PhD in Chemical Engineering or a related discipline and 2 years relevant experience
Experience with small scale cell culture models
Ability to operate bioreactors and understand bioreactor control systems
Conversant in bio-statistical methods and Design of Experiments (DoE)
Computer programming skills sufficient for programming of lab robots
Excellent communication skills (written and oral)
Ability to work collaboratively within a matrix organization
Experience with AMR15 micro bioreactors
High throughput automated cell culture systems
Experience with larger scale bioreactors (≥50L)
Demonstrated ability to lead projects
Job: Engineering & Maintenance
Primary Location: United States-Massachusetts-Framingham
Job Posting: Dec 1, 2016, 3:59:00 PM
Job Type: Regular
Employee Status: Regular