Pfizer Manager, Human Genetics in Cambridge, Massachusetts
A career at Pfizer offers opportunity, ownership and impact.All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
The advance of human genetics in recent years driven by the large scale human genome-sequencing and genome-wide association in multiple disease areas has brought the research community and pharmaceutical industry an unprecedented opportunity to utilize this information and technology to facilitate innovative drug discovery and development. We have now reached a key point at which human genetics is sufficiently mature to aid the drug discovery process in several important areas. A combination of genetic epidemiology, quantitative genetics, and functional genomics will facilitate our ability to identify mechanisms, indications, patients and biomarkers, guided by an evidence base in humans. Carefully designed and implemented pharmacogenetic studies of drug responses in clinical trials could provide novel mechanistic learnings to support combination therapy or biomarkers for patient stratification. Here, we are looking for an expert in human genetics with sound knowledge of applying quantitative methods to human genetics and genomics as tools for target discovery/validation, biomarker/indication identification, patient stratification through genetic association analyses and functional biology studies.
Provide quantitative genetics expertise and conduct analyses to derive impactful results through interactions and collaborations with the Neuroscience Research Unit and the Rare Disease Research Unit. *Provision of expertise and quantitative skill to the Research Unit on the application of genetics and functional genomics to inform: -Identification of novel therapeutic targets-Review and validation of therapeutic hypotheses-Mechanistic understanding of disease pathogenesis and causal pathways-Innovative approaches to identifying mechanism related biomarkers via integrating genetics with clinical and 'omic datasets.-Matching novel therapies to patients with relevant pathogenic trajectories. *Lead quantitative analysis, data integration, and methodology development for genetics projects by interacting with internal experts in statistics, bioinformatics, computational biology, and clinicians and research project leaders.Survey the literature and conferences for discoveries and findings from the broader genetics community. Integrate such findings into study opportunities and considerations internally.Responsible for implementation of the endorsed genetics strategy into the Neuroscience Research Unit and the Rare Disease Research Unit.Responsible for ensuring high-quality genetic data is incorporated into exploratory research programsResponsible for establishing and maintaining external collaborations to specified timelines and milestonesCommunicate and report study findings and analyses with leadership, administration, and collaborators.*Manage, support and promote relationships with the external community that can add value to target selection at Pfizer and enable collaborative use of Pfizer patient samples *Work collaboratively with other human geneticists in Pfizer at both a scientific and infrastructure level
PhD in genetics, statistical genetics, or genetic epidemiologyExpertise in genetics preferred in neurodegenerative or psychiatric disorders. *Sound statistical and quantitative skills, with working knowledge of epidemiological principals and population-based research. Experience: * Track record of innovative and impactful research in genetics of complex traits (peer-reviewed publications, preferably in the field of neurological disorders) or of rare disorders * Experience analyzing genetic data sets and integrating additional data types to further clinical and biological understanding. * Evidence of scientific leadership role with responsibility for research project delivery * Experience with multiple genetics platforms (chip-typing, WES & WGS, Sanger, custom capture targeted sequencing, etc.) as well as other genomic profiling technologies (microarrays, RNASeq, etc.). * Identifies, proposes and develops new methodology and analytical concepts * Able to effectively interact and communicate with multidisciplinary scientists, researchers and non-scientists - internally and externally Ideally, the candidate would also have one or more the following: * Post-doctoral studies in genetics of neurodegenerative disorders or in the genetics of rare diseases * Previous experience of the application of genetics to drug discovery or patient stratification * Proven track record of leading and delivering on multiple programs in parallel * Strong skills in statistical genetics including GWAS data analysis and NGS data interpretation
EEO & Employment Eligibility
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Manager, Human Genetics Cambridge, Massachusetts 1040704